Induction of general anesthesia with direct laryngoscopy and tracheal intubation is routine procedure but causes varying degree of sympathetic stimulation such as increasing in blood pressure and heart rate. Many approaches have been tried to
attenuate
these hemodynamic responses.
To evaluate the effects of nicardipine, a new calcium channel blocker, for prevent sympathetic stimulation induced by direct laryngoscopy and tracheal intubation, we administered nicardipine (40 mg P.O.) 60 minutes before laryngoscopy and
endotracheal
intubation.
60 patients, ASA physical status 1,2, scheduled operation, were selected randomly. We divided these patients into two groups. Group 1: control, valium 0.1-0.2 mg/kg P.O. (N=30), Group 2: valium 0.1-0.2 mg/kg with nicardipine 40 mg P.O. (N=30). We
measured systolic blood pressure, diastolic blood pressure and heart rate before premedication, before induction and 1,3,5,10 minutes after intubation in both groups and compared with control group.
@ES The results were follows;
@EN 1) Systolic blood pressure and diastolic pressure in nicardipine group were significantly decreased before induction after premedication.
2) After induction systolic blood pressure increases in both group (p<0.05) but increasing rate was significantly less than in nicardipine group (p<0.005).
3) After intubation diastolic pressure decreased significantly in nicardipine group (p<0.005).
4) The changes of heart rate were no difference in both groups.
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